New Risk for Sudden Death in Dialysis Patients

A low concentration of homoarginine in the blood seems to be a risk factor for sudden cardiac death and death from heart failure in diabetic patients who require hemodialysis, the researchers found.

Patients with the lowest levels homoarginine were about twice as likely to die suddenly during a study period of four years as those with the highest (HR 2.1, 95% CI 1.2 to 3.9), according to Christiane Drechsler, MD, PhD, University of Würzburg in Germany, and colleagues.

Those with the lowest level was also a three times more likely to die of heart failure (HR 3.3, 95% CI: 1.1 to 10.1), the researchers reported in the August issue of European Journal of Heart Failure.

"Longitudinal Evaluation homoarginine may be useful for monitoring the risk of dialysis patients," they write. "Beyond that, homoarginine may become a new promising target for therapeutic interventions in populations with high incidence of heart failure and sudden cardiac death."

Sudden cardiac death is a major cause of death in maintenance dialysis patients.Although some risk factors for sudden cardiac death in these patients were identified - including poor glycemic control and vitamin D - they do not fully explain the excess mortality.

Previous studies have suggested that homoarginine - a cationic amino acid - can increase the availability of nitric oxide, and an amino acid deficiency may increase the risk of endothelial dysfunction and infarction.

"We thought that endothelial dysfunction may play a crucial role in arrhythmogenesis in patients with renal failure and tested the hypothesis that low blood levels of homoarginine to increase the risk of sudden cardiac death in dialysis patients," Drechsler and colleagues.

They conducted a post hoc analysis of 1244 patients in the German 4D, which evaluated atorvastatin versus placebo in patients with type 2 diabetes who were treated by maintenance hemodialysis. The primary endpoint was a composite of cardiac death, stroke and MI.

The researchers measured the concentrations in blood samples obtained homoarginine base before the start of hemodialysis treatment or drugs. The average concentration was 1.2 mmol / L.

Low homoarginine concentrations were strongly associated with signs of heart failure, including congestive heart failure, left ventricular hypertrophy, and high levels of brain natriuretic peptide.

Male Health : Canine Congestive Heart Failure Treatments - Serving ...

There are probably a few words that most pet owners worried that "the canine heart disease. It will mean the eventual disappearance of the dog if nothing is done. Although there is no cure for heart problems very innate animal, dog congestive heart failure treatments are there that can help extend the life of your dog and improve its quality of life. First of all, they are specifically canine heart disease? This is often primarily when the heart of the dog does not run properly. The heart is created of four rooms, each operating with a set of valves.Heart Questions in pieces of the body when you stop working and the rest will be expected to compensate by exerting more effort. Although dogs are not primarily heart attacks expertise, these complications result in congestive heart failure, when left unchecked for too long. The symptoms of cough heart disease canine kiss, labored breathing, fainting, fatigue, and with bluish gray gums. In addition, because of blood pressure, fluid may begin to escape from a blood vessel in the dog. Accumulation of fluid then collects in the tissues and organs important alternative, moving into the abdominal cavity.Therefore, you also want to be careful if your pet has a distended belly. Most likely your options are drugs that will correct the flaws in the functioning of the heart. Specialty drugs specialize in canine binding capacity to reduce fluid accumulation, repair irregular heartbeat, and the increase of blood pumped by the heart. For some dogs, surgery is recommended. After an initial rest, resume regular exercise regimen for the dog. Apparently, the FDIC is out of cash again, but they should not be a surprise to anyone, we knew this would happen.Yes, the FDIC will want additional funding, and we tend to may well have an onslaught of bank failures due to inadequate budgets, especially after the crisis of industrial real estate, and the ongoing challenges of all seizures real estate. Although it is relatively easy to revive your own vision, people begin terribly rare, and some people fail. I will attempt an analysis of why people fail, from my own point of view, since I restored my sight. I suppose that people fail for two main reasons.

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